Study of CHS-114 in Participants With Advanced Solid Tumors

Active:	Yes
Cancer Type:	Head and Neck Cancer Skin Cancer (Non-Melanoma) Solid Tumor Unknown Primary	NCT ID:	NCT05635643
Trial Phases:	Phase I	Protocol IDs:	SRF114-101 (primary) NCI-2023-05019
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Coherus Biosciences, Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT05635643

Summary

This is a Phase 1, open-label, first-in-human, dose-escalation and expansion study of
SRF114, a monoclonal antibody that targets CCR8, as a monotherapy in patients with solid
tumors.

Objectives

This is a Phase 1, open-label, first-in-human, dose-escalation and expansion study of
CHS-114, a monoclonal antibody that targets CCR8, as a monotherapy in participants with
advanced solid tumors, that will be conducted in 3 parts:

- Arm 1a: CHS-114 monotherapy dose-escalation portion of the study will enroll
approximately 25 participants with advanced solid tumors.

- Arm 1b: CHS-114 monotherapy expansion cohort(s) will evaluate the safety, efficacy,
tolerability, pharmacokinetics, and pharmacodynamics of CHS-114 in indication
specific cohort(s). Up to approximately 10 participants will be enrolled.

- Arm 2: CHS-114 + toripalimab combination dose-escalation portion of the study will
evaluate the safety, efficacy, tolerability, pharmacokinetics, and pharmacodynamics
of CHS-114 in combination with toripalimab in indication specific cohort(s). Up to
approximately 6-12 participants will be enrolled.

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
404-778-5180
winshipcancer.emory.edu

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